((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone

Name	PF-06700841 tosylate
Synonyms	CS-2861 PF6700841 PF 6700841 PF6700841 PF-6700841 PF-06700841 PF-6700841 PF06700841 PF 6700841 PF 06700841 BREPOCITINIB PF-06700841 tosylate PF-06700841 TOSYLATE SALT ((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone ((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone
CAS	1883299-62-4

Molecular Formula	C18H21F2N7O
Molar Mass	389.4
Density	1.63±0.1 g/cm3(Predicted)
Boling Point	637.1±65.0 °C(Predicted)
Appearance	powder
Color	white to beige
pKa	7.28±0.10(Predicted)
Storage Condition	room temp
In vivo study	PF-06700841 pharmacokinetic studies in Sprague − Dawley rats after intravenous injection of 1 mg/kg PF-06700841 tosylate or oral administration of 3 mg/kg PF-06700841 tosylate, the plasma clearance of PF-06700841 in vivo was 31 mL/min/kg, the volume of distribution was 2.0 L/kg, and its oral bioavailability was 83%. After oral administration of 3 mg/kg, its Cmax was 774 ng/mL and auc∞ was 1340 ng · h/mL. The high oral bioavailability of PF-06700841 indicates that it has a high intestinal Absorbability, which is associated with its passive osmotic activity and high solubility in vitro.

biological activity	PF-06700841 (PF-841) is a potent Tyk2 and Jak1 inhibitor, the IC50 for Jak1 and Jak2 are 23 nM, 17 nM and 77 nM, respectively.
Target	Value
JAK1 (Cell-free assay)	17 nM
Tyk2 (Cell-free assay)	23 nM
JAK2 (Cell-free assay)	77 nM

Last Update：2024-04-09 21:04:16

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CAS: 1883299-62-4
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((S)-2,2-difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone Request for Quotation